Scientists create a detailed model of a virus with DNA inside (26 million atoms!). (Breakthrough)

Goal: Understand virus structure and DNA dynamics for better drug development. (Traditional targets - surface or replication proteins - may be limited.)

 HK97 virus, well-studied for comparison with simulations


Simulating DNA packaging requires long timescales - impossible for high detail


Multiresolution approach: different levels of detail combined for a complete picture


First look at DNA packaging process and final structure inside the capsid


DNA forms switchback loops (similar to eukaryotic cells) and organizes into capsid-shaped domains. (Individuality observed, even in viruses!)


Common structural features (defects) identified as potential drug targets. (Opens doors for studying other viruses, including RNA types.)


 This research paves the way for better understanding viruses and developing new antiviral treatments.

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