Scientists create a detailed model of a virus with DNA inside (26 million atoms!). (Breakthrough)

Goal: Understand virus structure and DNA dynamics for better drug development. (Traditional targets - surface or replication proteins - may be limited.)

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HK97 virus, well-studied for comparison with simulations

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Simulating DNA packaging requires long timescales - impossible for high detail

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Multiresolution approach: different levels of detail combined for a complete picture

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First look at DNA packaging process and final structure inside the capsid

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DNA forms switchback loops (similar to eukaryotic cells) and organizes into capsid-shaped domains. (Individuality observed, even in viruses!)

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Common structural features (defects) identified as potential drug targets. (Opens doors for studying other viruses, including RNA types.)

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This research paves the way for better understanding viruses and developing new antiviral treatments.

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Don’t Get Left Behind! AI Expertise Pays Up to 44% More

[{"selector":"#anim-9bbb7aa6-233a-41a4-8901-b8a044892b75","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-b1dd8a65-13e1-456e-8cc9-b79aca15827b","keyframes":{"transform":["translate3d(103.65534%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Learn more

Microsoft Launch AI powered Paint NPU app in March

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Scientists create a detailed model of a virus with DNA inside (26 million atoms!). (Breakthrough)

Goal: Understand virus structure and DNA dynamics for better drug development. (Traditional targets - surface or replication proteins - may be limited.)

HK97 virus, well-studied for comparison with simulations

Focus

Simulating DNA packaging requires long timescales - impossible for high detail

Challenge

Multiresolution approach: different levels of detail combined for a complete picture

Solution

First look at DNA packaging process and final structure inside the capsid

Results

DNA forms switchback loops (similar to eukaryotic cells) and organizes into capsid-shaped domains. (Individuality observed, even in viruses!)

Findings

Common structural features (defects) identified as potential drug targets. (Opens doors for studying other viruses, including RNA types.)

Implications

This research paves the way for better understanding viruses and developing new antiviral treatments.

Don’t Get Left Behind! AI Expertise Pays Up to 44% More

Microsoft Launch AI powered Paint NPU app in March